Inflammatory and Autoimmune Diseases

Inflammatory and autoimmune diseases are a large group of disorders that encompasses a vast variety of human diseases, such as psoriasis, rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, multiple sclerosis and inflammatory bowel disease etc. Hunting medicines to address these unmet medical needs are one of the most popular therapeutic areas for drug discovery. HitGen dedicates to provide solution to drug discovery of inflammatory and autoimmune diseases area.

Services for inflammatory and autoimmune diseases drug discovery and development

• Target validation

• Recombinant target protein production

• Biochemical assays development

• DEL screening

• Hit identification and generation

• Hit-to-lead

• Lead optimization

• Fragment-based drug discovery and structure-based drug discovery

• Co-crystal structure generation and resolution

• In vitro efficacy and ADME evaluation

• In vivo pharmacology (IMQ, EAE Modeling)

• Drug metabolism and pharmacokinetics (DMPK) 

• Safety study

• IND submission