DMPK

Drug metabolism and pharmacokinetics (DMPK) study investigate the absorption, distribution, metabolism and excretion (ADME) character of drug with a variety of technologies, which provide data for optimization of drug to acquire desirable in vivo performance, as well as predicting the ADME of drug when dosing to human.

In vitro/in vivo DMPK tools are throughout used in drug development. Based on DNA encoded library-directed drug development, HitGen has built a fast, economic and high-throughput DMPK study platform to support different stages of drug development from hit screening, lead optimization towards PCC confirmation.

In vitro DMPK 

• Microsomal stability for multiple species (H, Ms, R, D, MK)

• Hepatocyte stability for multiple species (Ms, R, D, MK)

• Microsome/Hepatocyte-based metabolite identification/GSH adduction

• Plasma protein binding

• Cell uptake and efflux

• CYP450 inhibition assay

• PAMPA-based permeability assay

In vivo DMPK 

• General pharmacokinetics

• Cassette PK screening for multiple compounds

• In vivo metabolites identification 

• Tissue distribution