DMPK

HitGen provides complete pre-clinical DMPK study to support IND of candidate compound. The services include complete in vivo/in vitro investigation on absorption, distribution, metabolism, excretion (ADME) and drug-drug interaction character of candidate. We also has DMPK experts interpreting the data and making rationale strategy for preclinical safety evaluation

Absorption

• Full PK on mouse, rat and dog

• Cell permeability: Caco-2 or MDCK based permeability assay

Distribution

• Plasma/Tissue protein binding screening for multiple species

• Tissue distribution for multiple species

Metabolism

• CYP enzyme phenotyping/inhibition/induction assay

• Microsome/Hepatocyte stability assay

• Microsome/Hepatocyte/Animal-based metabolite identification

Excretion

• Non-radiolabeled excretion for mouse, rat and dog (feces, urine and bile)

Drug-Drug Interaction

• ABC/SLC transporter dependency assay

• ABC/SLC transporter inhibition assay