Press Release

Infographic | HitGen FY2022 Q3 Report

20 October 2022 – C4X Discovery Holdings plc (“C4XD”, AIM: C4XD), a pioneering Drug Discovery company, and Shanghai Stock Exchange listed company HitGen Inc. (“HitGen”, SSE: 688222.SH), a world leader in the development and application of DNA-encoded library (DEL) technology, today announce a research collaboration project to identify novel, small molecule hits against an inflammatory target for further C4XD development.

Cambridge UK, and Copenhagen, Denmark, 27 September 2022 – Vernalis Research (“Vernalis”), a fully owned subsidiary of HitGen Inc., and Contera Pharma A/S (“Contera”) are pleased to announce a strategic drug discovery collaboration on an undisclosed target.

Cambridge UK, and Boston, US, 5 September 2022 – Vernalis Research (“Vernalis”), a fully owned subsidiary of HitGen Inc., and Unison Medicines Inc. (“Unison”) are pleased to announce a research collaboration on an undisclosed bacterial target.

CHENGDU, China, July 27, 2022 – Shanghai Stock Exchange listed company HitGen Inc. (“HitGen”) today announced that it has entered into a research collaboration agreement with LoQus23 Therapeutics Ltd. (“LoQus23”), a private biotechnology company discovering small molecule therapies that target aberrant DNA damage repair to treat Huntington's disease and other triplet repeat diseases (TRDs). HitGen will apply its DNA-encoded library (DEL) technology platform to discover compounds that bind to certain targets that are of interest to LoQus23.

Almac Discovery, the research driven drug discovery company and a member of the Almac Group, today announced a new research collaboration with HitGen Inc. (SSE: 688222.SH), a world leader in the development and application of DNA-encoded library (DEL) technology for novel chemical equity (NCE) generation. The collaboration is focused on the identification of novel compounds against selected Deubiquitinating enzymes (DUB) targets of strategic interest to Almac.

CHENGDU, China, May 13, 2022 – HitGen Inc. (“HitGen”), a Shanghai Stock Exchange STAR-listed company, and Arclight Inc. (“Arclight”), an early stage biotech company focused on innovative approaches to solving the challenges of neurodegenerative disease drug discovery and company creation, today announced a five-year strategic collaborative research and license agreement. The strategic collaboration will focus on discovery and development of innovative drugs in the central nervous system (CNS) therapeutic area using HitGen's DNA-encoded libraries (DEL) and Targeted Protein Degradation (TPD) platforms.

Infographic | HitGen FY2021 Annual Report

CHENGDU, China, April 19, 2022 – HitGen Pharmaceuticals Inc. and the PACS1 Syndrome Research Foundation announce an agreement focused on the application of HitGen’s DNA-encoded library (DEL) technology to identify ligands that could selectively bind to the mutated PACS1 Protein and therefore serve as a treatment or a cure for patients with PACS1 Syndrome.

CHENGDU, China, April 6, 2022 – HitGen Inc. (“HitGen”), a Shanghai Stock Exchange STAR-listed company, today announced that the company has successfully completed the multiple-target drug discovery research projects with UPPTHERA, a Korean pharmaceutical company aiming for new drug development employing “Protein Degradation Technology”. During the collaboration, multiple undisclosed targets were screened against HitGen’s proprietary over 1 trillion DNA-encoded libraries (DELs). The majority of the targets have resulted in confirmed hits, which have high potential for PROTAC development. Now the two parties are extending the collaboration on further development of these projects and additional challenging targets.